Oncotarget Published Study Reveals What Antibiotics Do to Cancer Cells

Could cancer be treated with conventional antibiotics? In a study, published on Oncotarget, researchers introduce a new scenario to treat the disease. Together with British colleagues, and researchers from New York and Philadelphia, scientists have tested five different antibiotics on cancerous cell lines from eight different tumor types.

The five antibiotics used were Azithromycin, Doxycycline, Tigecycline, Pyrvinium Pamoate, and Chloramphenicol. Four of these antibiotics destroyed the cancer stem cells in each test. This was true for glioblastoma, the most aggressive form of a brain tumor, as well as cancers of the lung, prostate, breast, and skin. Researchers believe the reason the antibiotics may be as effective on these cells is because of the negative impact on the mitochondria. Oncotarget is also available on Dove Press.

According to the researchers, these cancerous cell components are also referred to as the power plants of cells. They supply energy needed by cancer stem cells, for example in order to grow and divide, allowing tumors to grow. One explanation is that mitochondria are derived from bacteria. Therefore, these antibiotics can be used against that bacteria. Lead researcher, Professor Michael P. Lisanti says he was aware of the impact antibiotics had on the mitochondria, and the significance for tumor growth. He believes if the connection between antibiotics and the eradication of cancer stem cells are confirmed, we could be using this strategy soon, which would make anti-cancer drugs more affordable.

Oncotarget researchers were brought together from the Manchester Cancer Research Centre, National Cancer Institute, National Institutes of Health, Breakthrough Breast Cancer, with funding from the University of Manchester and ERC Advanced Grant. The report was published on Oncotarget, a respected peer-reviewed online journal that focuses on Oncology topics.

Visit: https://www.facebook.com/Oncotarget/

Each year, thousands of research reports are published on Oncotarget, and when it comes to oncology journals, they rank number one. This free access to scientific findings help maximize visibility by offering a wide distribution of information to colleagues and the public.

Roberto Santiago’s Role of Developing Malls in Brazil

Roberto Santiago is a renowned Brazilian entrepreneur born in Joao Pessoa in 1958. Roberto is popularly recognized for establishing some of the largest shopping malls in Brazil. One of the famous malls established by the entrepreneur is the Roberto Santiago Manaira Shopping which is located in the city Joao Pessoa, Paraiba. The construction of this mall started in 1987 and completed two years later. After the facility was launched close to 30 years ago, it has undergone five expansions to offer customers more options. The Manaira Shopping has a variety of retail outlets, entertainment facilities, food courts, shopping stores, financial institutions, gymnasium and a college.

Facilities at Manaira Shopping Mall

Inside Manaira Shopping center there is Domus hall located at the rooftop of the mall. It is one of the expansions added to the mall. It was opened in 2009, and has adequate space for events like exhibits, weddings, conferences, musical concerts, graduation events and others. The Domus hall has a capacity to hold about 10,000 individuals standing, and 4,000 seated. The hall has HVAC systems installed to ensure there is excellent air circulation. The hall has soundproof gadgets to prevent disrupting other activities within the mall. It has been equipped with state-of-the-art sound devices to offer fans entertainment they deserve. The Domus hall has hosted musicians and artists from Brazil as well as from abroad. Read more on pbnews.com.

The Manaira Shopping complex has the best movie theaters that feature the very recent and latest movie. The movie area has 11 rooms fitted with advanced and 3D amenities. In addition, there is a VIP section. The gaming area is fantastic to accommodate all including the young and old. The mall has several food stores including restaurants, food courts, Gourmet and Waynes. The food court section of this mall has been redeveloped several times, particularly in 2008, 2012 and 2014 in order to offer customers more food variety depending on their budgets.

People who visit Roberto Santiago Manaira Shopping have a variety of options to choose from. The mall has more than 250 shopping stores dealing in different products and services such as sportswear, furniture, clothes, jewelry, and whole lots of other products including food stuffs. There are constituent colleges at the mall to enable those who want to further their study join the college of their choice.

Visit: http://www.pbagora.com.br/conteudo.php?id=20111106140504

About Roberto Santiago

Under the leadership of Roberto Santiago, Manaira Shopping has emerged as a top shopping destination for residents and visitors of the state of Paraiba and surrounding areas. The mall is recognized for providing clients with top level entertainment, leisure and fun. The entrepreneurial skills of Santiago enabled him to design and redevelop the mall to meet the growing needs of customers. Mangabeira Shopping Center is another mall owned by Santiago. The mall has similar features and facilities like Manaira Shopping. The objective of Santiago is to concentrate a wide variety of products and services under one location, and hence saving customers and money they would have used to move to different locations.

Cassio Audi’s Early Career in Music

When people hear the name Cassio Audi, they automatically think of him in the financial and business sector. Earlier on in his life, he had started a career in music that he wanted to pursue in 1985. He had a band with fellow members; Andre Machado, Pit Passarell, Yves Passarell and Felipe Machado. He was involved in music until the year 1989 when he went to the business world.

The band, mainly Cassio Audi, were inspired by Iron Maiden and the metal genre of music that was becoming prominent in Britain. Cassio was excellent in playing the instruments, and his fans were disappointed when he left the music career to go to the corporate world.

His expertise in drums was evident, he became known in the whole world when they released the album, “The Killer Sword” that had good tracks like Nightmare, Princes from Hell, and Killera some of these songs were also included on the 1987 album “Soldiers of Sunrise” that Audi played the drums. People and fans saw their raw talent and said that with a little refurbishment, they would have been the world’s most celebrated band.

Allmusic gave their album a four-star recognition. From the time they released the first album, it has been recreated and released again. “Theatre of Fate.” was their second album that was more popular compared to the first. He went to campus where he reduced performances and tours and graduated with a bachelor’s degree in business administration. Cassio Audi holds an MBA in Finance from the University of Sao Paolo. He is now well skilled in the business world and especially in the management of finance. On top of these, he has some expertise in the real estate development, and he is well acquainted with issues that involve the stock exchange market in his country, Brazil.

George Soros Backs Effort to Remove Arpaio

Not known for sitting out a good political fight, billionaire investor and philanthropist George Soros dropped $2 million in support of the fight to remove Arizona’s infamous Sheriff Joe Arpaio.

Maricopa Strong, a PAC Soros started, filed finance documents that show the investor has committed millions to remove Arpaio from his long-held position in Maricopa County. Joinging him in this effort is Laura and John Arnold, known for their role in Texas energy, and Laurene Powell Jobs, widow of the late Apple CEO Steve Jobs, for $500,000 and $250,000 respectively.

For Soros this is another local election he’s decided to weigh in on, continuing a trend that started back in 2015. Soros has backed several groups in cities to remove district attorneys. This began in Harris County, Houston, Texas, where Soros spent $1 million on local elections; $1.5 million went to Jefferson and Gilpin counties in Denver, Colorado to remove incumbents; and again in Maricopa County to remove Republican Bill Montgomery from the local government.

While those other elections may have flown under the radar of national news, the fight for Maricopa County is high profile. Arpaio is known as a conservative darling, despite being at the center of several investigations over his routine use of discriminatory treatment of the local immigrant community, and this gives media on the right an opportunity to cast Soros as a shadowy power player. Learn more on Discover the Networks about George Soros.

Soros has long championed causes of immigrants and human rights abuses. That he would pick this election to get involved in makes sense.

More than $2.9 million has been spent in media ads supporting Democrat Paul Penzone and attacking Arpaio on his failure to take Maricopa County’s issues with sexual assault seriously. Arpaio’s response has been to deflect and attack Soros with a barrage of conspiratorial epithets

In defense of his decision to take on Arpaio and change the criminal justice head in that county, Micheal Vachon, a spokesperson for Soros, claimed that Arpaio has continually violated civil rights in Maricopa County for over 20 years. And that has given Arpaio a platform that he has continually used to spread hateful messaging directed to immigrant communities across the country. By getting involved in this local election, George Soros was given an opportunity to give the values of justice and inclusion a means by which they could compete with Arpaio’s celebrity while also removing hate and intolerance from at least one theater in the realm of politics. Read this story at Politico.com about George Soros.

Arpaio, however, hasn’t been without support of his own. Using his name recognition as well as donors sympathetic to his positions, Arpaio has been able to spend $2.8 million in media ads and appear on national news with enough regularity that it acts as an advertisement of its own.

Combining name recognition and money has made for a winning combination. Arpaio has out-raised and spent Penzone, but that doesn’t necessarily translate into votes.

A grassroots movement to remove Arpaio has brought in backers from Washington, including Rep. Ruben Gallego, a fellow Democrat and founder of a PAC that supported Penzone in his unsuccessful 2012 run. What’s changed since then is Soro’s inclusion, which has taken the effort to remove Arpaio from a couple hundred thousand dollars to millions.

Know more: http://www.businessinsider.com/george-soros-billionaire-investor-profile-2017-1

Lifeline Screening Can Make The Difference Between Good Health And Bad

There are many ailments that tend to go unnoticed by us as we trek throughout our lives, yet manifest as “sudden” ailments later on. If we are smart, we would have periodic checkups from time to time from our doctor, but sadly most of us don’t take advantage of that availability.

Many such bodily ailments can be discovered early on by a process called screening. In a variety of ways, medical experts can perform a screening and discover what actions can be taken to preserve our health.

Lifeline screening provides several forms of tests that can be given without going to a doctor’s office or a hospital to have them done. These are routine scans that are given at discounted prices that will do basic health scans on equipment not usually found in a doctor’s office, but in hospitals and testing facilities.

Lifeline Screening provides tests using three basic technologies. One is ultrasound, a second is finger-stick blood screenings, and the third is a limited electrocardiograph.

The are similar to when a mother gets a screening for a new baby in the womb. Sound waves are sent out, and the image of the internal organs show up on the screen in real time. This type of test can show if blood vessels are blocked, such as the carotid arteries or the abdominal aortic vessel to test for an aneurysm. The Ankle-brachial index screening can be performed to test for peripheral arterial disease as well as a test for bone density to test for osteoporosis.

The finger-stick blood test can give a complete lipid blood panel, as well as a glucose screening to check for blood sugar levels, a CRP screening for cardiovascular disease and elevated liver enzymes.

A limited cardiograph tests for atrial fibrillation, which is an irregular heartbeat, also called A-fib. This can be serious, yet it can go unnoticed by an individual.

All the results of the screenings can be made available to a person’s doctor for evaluation.

End Citizens United Donate Over $4 Million to Fight Rigging of the System

Introduction

In 2010, the Supreme Court ruled against the Citizens United in a case with F.E.C. This decision completely transformed the political landscape of the United States of America. The court proceeded with its strategy to establish a legal basis that humans are corporations and vice versa. This probed billionaires into spending unlimited money in political campaign and elections. The result was no accountability or transparency. In fact, most billionaires like the prominent Koch brothers have been trying to get into politics. The cycle continues with many high profile citizens illegally delving into political power.

History

End Citizens United was founded on March 1st, 2015. It is a committee for political action supported by grassroots donors. The organization is committed to countering disastrous effects geared towards interfering with the lives of citizens. The committee fixes these issues through reforming the campaign finance system. The aim of End Citizens United is showing the elected officials, voters, and candidates that the grassroots’ commitment is fighting against the billionaires who focus on buying elections. The primary objective of the group is building a strong coalition focused on campaign finance reform. Additionally, the organization pressures policy makers to act against these political offenders.

Mission

The mission of End Citizen United is battling big money spenders in politics who rig elections. The organization does this by electing champions for campaign finance reforms. Also, the committee passes state ballot measures. The selected champions strategize on overturning Citizens United by putting a stop to unlimited money spending in politics. End Citizens United is controlled by a belief in the power of money transparency. They practice what they preach. The group’s recent filing with the commission of federal elections was filled on February 20, 2017.End Citizens United implements this mission through the following steps:

  • Electing active reformists
  • Whistleblowing on the issues of political money
  • Deploying grassroots membership for political demonstration

End Citizens Contribution

On 4th April 2017, the news headlines were filled with reports concerning End Citizen’s collection of over $4 million with a projection of raising $35 million before the 2018 congress elections. USA Today provided this report. The amount would be higher than the total amount the group raised in 2016, towards the just completed presidential elections. In that year, approximately 100,000 people made contributions to the PAC. That marked the first quarter of the year. 40,000 people made their first contribution.

According to Tiffany Muller president and executive of PAC, their core objective is to elect champions for campaign finance reforms to Congress. Muller added that the current average contribution of PAC is $12 million. The donors felt like they had been rigged out of the system. According to them, the highest bidder gets power. Donating millions towards the fight was their way of hitting back. Also, the furious Democrats were willing to contribute towards fighting Donald Trump and his government.

Construcap Offers Finer Construction Options For Businesses

There are many new construction projects starting today in Brazil, and a number of them have started with Construcap. This is one of the largest companies in all of Brazil, and they are a leader in development that has helped with the building of venues for the Olympics and World Cup. This article explains how someone may engage with Construcap on a new construction project at http://www.construcap.com.br/pt/fale-conosco/assessoria-de-imprensa, and they will find it easier to build something of high quality.

#1: The Company Has Reputation

Construcap has a reputation to uphold as it has been on the forefront of construction in the country for some time, and they are known for the lovely work they do. They are creating new opportunities for all their clients. Anyone who needs guidance may come to Construcap for help as they will receive a proper plan that makes it much easier to build.

#2: Scheduling Construction

The company is one of the busiest in the country, and they will find work crews who are ready to begin the construction of anything that is large or small. The country has been growing steadily for the last ten years, and it will continue to do so for many years to come simply because the projects that are done by Construcap.

#3: The Company Has Many Resources

Anyone who has come to Construcap for help will find it simple to ask the company they would plan to complete their desired project. The company has a definitive plan in place for every client, and they are searching for simple ways to save their customers money. The customers who come to the company for help will receive a plan of action on pciconcursos.com.br, and they will use that plan of action to ensure they are building something that will stand through the ages.

There are many companies in Brazil that are relying on Construcap, and they will ask the company how they may make the most of a new construction build on YouTube.com. Each build will be beautiful, and it will be built to the standards of the industry with fine materials and the best work crews.

Karl Heideck – The Attorney You Want to See

When it becomes necessary to defend or enforce a legal right between two opposing parties, the procedure involved is known as litigation. Often times litigation can be settled by agreement between the parties involved, but in many instances, the issue can be decided by a judge or jury. At the time that an individual or individuals decide to defend or enforce their legal rights, the litigation process begins, usually with the hiring of an attorney. For the litigation to be successful, detailed investigation into the matter must be conducted by the attorneys of all parties involved to determine if there is enough evidence for a lawsuit to be filed. This may require document research, finding witnesses, and collecting statements from witnesses.

The education of a litigation attorney can be extensive. The individual must first earn a bachelor’s degree from an accredited college or university. Although a specific major isn’t required, common majors for pre-law can include criminal justice, history, political science, and English. To be admitted into Law School, the student must take and pass the Law School Admissions Test. A full time student can expect to spend at least three years in study.

One such attorney in the Philadelphia area is Mr. Karl Heideck. Mr Heideck received his Bachelor’s Degree of Arts degree in English and Literature from Swarthmore College and graduated with Honors from the Temple University School of Law. His areas of expertise cover Legal Writing, Employment Law, Civil Litigation, Corporate Law, Legal Research, Commercial Litigation, and Intellectual Property Law.

Karl Heideck began his career as an associate at Conrad O’Brien where he worked in commercial litigation. He also worked as a property attorney at Pepper Hamilton LLP where he reviewed and analyzed government documents. Mr. Heideck also has extensive experience working in bankruptcy and white collar defense.

Source: https://www.lawyer.com/karl-heideck.html

Study Suggests Stem Cell Treatment May Lead to MS Remission

The results of a recent clinical trial show that transplanting a person’s own stem cells back into them, after high-dose immunosuppressive therapy, can cause long-term remission of multiple sclerosis. Multiple sclerosis (MS) is a disease in which the nervous system is attacked by the immune system. In the study 69% of the patients had lived for 5 years with no remission of MS symptoms, brain lesions or progression of the disease. The patients had not been given any multiple sclerosis medicines during this time.

The clinical trial was funded by the National Institute of Allergy and Infectious Diseases. The three year results were published in 2014 and the five year results were published this month.

The findings of the trials suggest that this treatment is more effective than other MS medicines have shown to be. The next step will be to develop a larger trial to directly compare this treatment path to other MS medicines.

The symptoms experienced by people suffering from MS can include fatigue, chronic pain, weakness and motor and speech difficulties. Over time the symptoms can get progressively worse as the disease develops.

The clinical trial used volunteer sufferers of multiple sclerosis from the ages of 26 to 52 years old. These patients had been taking available MS drugs but were still experiencing a worsening in their conditions.

A doctor that has extensive experience in handling patients with MS is Dr. Shiva Gopal Vasishta. Dr. Shiva Gopal Vasishta earned his degree in medicine and psychiatry in 1979 from the Government Medical College in India. His residency was performed at Boston City Hospital.

Dr. Shiva Gopal Vasishta has a practice at Eastern Neurodiagnostic Associates where he treats patients with brain disorders, including multiple sclerosis. In order to help his older patients, Dr. Shiva Gopal Vasishta does accept Medicare.